fibrotic diseases — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T16378	Ogerin		Others , 5-HT Receptor , Adenosine Receptor
	Ogerin is a selective GPR68 positive allosteric modulator (pEC50: 6.83). Ogerin blocks recall in fear conditioning in mice. Ogerin displays inverse agonist and antagonist activity (Ki, 220 nM) at A2A receptor and weak an...		Others , 5-HT Receptor , Adenosine Receptor
T22086	HA 155	Autotaxin Inhibitor IV	PDE
	HA 155 (Autotaxin Inhibitor IV) is a boronic acid-based compound, inhibiting ATX with IC50 of 5.7 nM by selectively binding to its catalytic threonine.		PDE
T12371L	PAT-1251		Monoamine Oxidase
	PAT-1251 is an inhibitor of LOXL2 with IC50s of 10, 0.12, and 0.16 μM for the mouse, rat, and dog and can be used in studies about fibrotic diseases.		Monoamine Oxidase
T69913	Lenumlostat	PAT-1251,GB2064	Monoamine Oxidase
	Lenumlostat is an orally available, selective and potent lysyl oxidase-like protein 2 (LOXL2) inhibitor with inhibitory effects on hLOXL2, hLOXL3 and LOXL2 for the study of fibrotic diseases.		Monoamine Oxidase
T38164	MnTBAP chloride	Mn(III)TBAP
	MnTBAP chloride (Mn(III)TBAP) is a cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger that reduces the doubling time of SOD-E. coli by a factor of 2. MnTBAP chloride exhibits anti-inflammatory ...
T39798	S1P2 antagonist 1
	S1P2 antagonist 1 is an orally bioavailable S1P2 antagonist against fibrotic diseases.
T23472	Tranilast Sodium		Others
	Tranilast Sodium has been used for the treatment of bronchial asthma. Tranilast is also used to autoimmune diseases, atopic and fibrotic pat.		Others
T70275	PAT-347
	PAT-347 is a potent Autotaxin Inhibitor. Autotaxin (ATX) is a secreted enzyme responsible for the hydrolysis of lysophosphatidylcholine (LPC) to the bioactive lysophosphatidic acid (LPA) and choline. The ATX-LPA signali...
T80560	Tulisokibart	PRA-023,PRA023
	Tulisokibart (PRA023) is a humanized IgG1-κ monoclonal antibody that targets TNFSF15/TL1A, with potential applications in researching various inflammatory and fibrotic diseases, including Crohn's Disease (CD) [1] [2].
T76526	Ac-D-DGla-LI-Cha-C
	Ac-D-DGla-LI-Cha-C is a potent peptide inhibitor of the HCV protease, applicable in research targeting a range of diseases, including cancer, autoimmune, fibrotic, inflammatory, neurodegenerative, infectious, lung, heart...
T62302	ALK5-IN-28
	ALK5-IN-28 is a selective inhibitor of ALK-5 with an IC50 ≤ 10 nM that inhibits TGF-β-induced SMAD signalling.ALK5-IN-28 has the potential to inhibit tumour growth in vivo.ALK5-IN-28 can be used to study proliferative di...
T62394	ALK5-IN-31
	ALK5-IN-31 is a selective inhibitor of ALK-5 (IC50≤10 nM) and also inhibits TGF-β-induced SMAD signalling.ALK5-IN-31 has the potential to inhibit tumour growth in vivo.ALK5-IN-31 can be used in the study of proliferative...
T62395	ALK5-IN-32
	ALK5-IN-32 is a selective inhibitor of ALK-5 (10 nM
T63498	ALK5-IN-6
	ALK5-IN-6 is a potent inhibitor of ALK5. ALK5-IN-6 has potential for TGF-β-related diseases and conditions, including but not limited to tumors, inflammatory diseases, fibrotic diseases, autoimmune diseases, etc.Among th...
T63809	Ansornitinib
	Ansornitinib is an oral, active dual kinase inhibitor that inhibits platelet-derived growth factor receptor (PDGFR) and vascular endothelial growth factor receptor (VEGFR2).Ansornitinib is an antifibrotic agent that can ...
T78585	Pentabromopseudilin
	Pentabromopseudilin (PBrP), a marine antibiotic derived from Pseudomonas bromoutilis and Alteromonas luteoviolaceus, demonstrates antimicrobial, antitumor, and phytotoxic properties. It acts as a reversible, allosteric i...
T60438	PXS-6302
	PXS-6302 is an irreversible inhibitor of lysyl oxidase with IC50s of 3.7 μM for Bovine LOX, 3.4 μM for rh LOXL1, 0.4 μM for rh LOXL2, 1.5 μM for rh LOXL3, 0.3 μM for rh LOXL4, respectively. PXS-6302 can readily penetrate...